A Valuable Partner

Our unique approach to R&D goes beyond science and makes us an ideal partner for pharmaceutical companies and others working in the HCV and antibacterial arenas. Being nimble, while maintaining focus allows us to work with a variety of partners to bring our research to where it will do the most good.

Today, we are working collaboratively with our partners; AbbVie (the former research-based pharmaceutical business of Abbott Laboratories), and the National Institutes of Allergy and Infectious Disease (NIAID), who share our goals of advancing our compounds as quickly as possible in order to treat a variety of serious infections.

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AbbVie (formerly Abbott Laboratories)

In December 2006, Enanta and Abbott announced a worldwide agreement to collaborate on the discovery, development and commercialization of HCV NS3 and NS3/4A protease inhibitors and HCV protease inhibitor-containing drug combinations. Under the agreement, Abbott (now AbbVie) is responsible for and funds all costs associated with the development, manufacture and commercialization activities of ABT-450, ABT-493 and any other compounds under this agreement. We received $57 million upon signing the collaboration agreement and Abbott’s simultaneous purchase of Enanta preferred stock and a total of $95 million of development milestone payments. We are eligible to receive additional regulatory approval milestones, as well as annually tiered, double-digit royalties  per product, based on annual net sales allocable to ABT-450 or to any of our collaborations’ additional HCV protease inhibitors.

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In February 2012, we entered into a Collaboration and License Agreement with Novartis granting Novartis exclusive, worldwide rights to develop manufacture and commercialize EDP-239, our lead compound from our NS5A inhibitor program, and other NS5A compounds. In September, 2014, Novartis informed us that HCV research was no longer a strategic focus for Novartis and we entered into a new agreement to regain full rights to EDP-239 from Novartis.

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National Institutes of Allergy and Infectious Disease (NIAID)

In September 2011, we were awarded a contract from NIAID to fund preclinical and early clinical development of a new class of bridged bicyclic antibiotics known as Bicyclolides. The Bicyclolides are to be used as medical countermeasures against multiple biodefense bacteria found in anthrax, plague and tularemia. The contract has an initial term of 30 months ending on March 30, 2014. NIAID has the option to extend the contract up to 6 times. If each option period is exercised, the contract would be extended until September 29, 2016. The initial award under the initial term was $14.3 million, with the possibility of up to a total of $42.7 million if each option period is exercised by NIAID.

Additionally, Enanta has focused on bicyclolides for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE) and resistant streptococci.  All current development activities are focused on intravenous and oral formulations of EDP-788, with additional IND-enabling studies in progress. Our preclinical development of EDP-788 is funded under our contract with NIAID, with potential for further NIAID funding of early clinical development